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The development of antibiotic resistance is an increasing threat to global public health. In a recent study, researchers from Graz, Austria present new perspectives on how to meet this major challenge.
What is Antibiotic resistance?

Antibiotic resistance occurs when bacteria change in some way that reduces or eliminates the effectiveness of drugs, chemicals, or other agents designed to cure or prevent infections. The bacteria survive and continue to multiply causing more harm. This resistant nature can become deadly to those infected with such antibiotic resistant bacteria, making it harder to treat infections.

This can lead to a patient’s condition drastically worsening and, in some cases, death. The number of deaths and diseases that are caused by antibiotic-resistant pathogens is increasing around the world. The World Health Organization (WHO) considers this disturbing rise in antibiotic resistance to be a major challenge that must be treated with the highest urgency.

New findings support an issue

Head of the Institute of Environmental Biotechnology at TU Graz (Graz University of Technology) Gabriele Berg has initiated research into why this is and found some interesting results. Berg’s research group was conducted with the Medical University of Graz’s national partners and looked into how the level of cleaning measures influenced the development of antibiotic resistance.

The study focused on the antibiotic resistances to all existing microorganisms within both clean spaces that were therefore subject to a strong microbial control and areas that had little to no microbial controls. The study used the following three areas for this: TU Graz’s Department of Internal Medicine’s intensive care unit, both private and public buildings with little to no microbial control, and clean rooms within the aerospace industry that have significantly powerful microbial control.

Findings from the research showed that microbial diversity decreased in the clean and controlled spaces, however what increased in these highly hygienic areas were the variety of resistances.

What was also found in significant quantities in these controlled spaces was opportunistic bacteria; bacteria that infects hosts with immune deficiencies.

What the controlled, excessively hygienic spaces were also lacking was bacteria that is beneficial to a person’s health, e.g. bacteria that strengthens immune systems. Director of studies at TU Graz’s Institute of Environmental Biotechnology Dr. Alexander Mahnert explains the results as follows: “In environments with strong microbial control in the ICU and industrially used clean rooms, there are increasing antibiotic resistances with a high potential for combining with pathogens.”

These results therefore indicate that by having, and maintaining, a secure microbial diversity in hospitals, this increase in antibiotic resistance could be counteracted, and further significantly reduced. Berg comments on the findings from these results, stating that:

“The microbial control of pathogens is already being successfully used in cultivated plants and also in humans in the framework of stool transplantation. Our study provides an initial foundation to pursue such ideas in indoor areas in the future.” The TU Graz team have future plans to create biotechnological solutions to make the implementation of a controlled microbial diversity in hospitals a reality.

Beyond antibiotics, hospitals and clinics are expected to maintain a high hand hygiene compliance and prevent germs spreading through hygienic surfaces, hand washing stations, antibacterial hand wash and have a company culture that maintains cleanliness at the front of its organization.

What this study has shown is that excessive hygiene really can strengthen antibiotic resistance, and therefore provides both an answer and the potential for a solution to this worldwide issue of antibiotic resistance. This would therefore lead to better management of bacterial infections overall, significantly reducing the number of deaths from this currently global cause for concern.

Maybe we will sooner than later see new sanitizing products enter the market with focus on preserving the positive bacterial diversity on hands and only killing the bad bacteria.

No matter the outcome, proper hand hygiene will always be a big part of the solution and because Sani nudge is dispenser and product agnostic, we support the evolution of hand cleaning products.


Source: https://www.tugraz.at/en/tu-graz/services/news-stories/media-service/singleview/article/uebertriebene-hygiene-foerdert-antibiotikaresistenz0/